Global donor and acceptor splicing site kinetics in human cells
نویسندگان
چکیده
منابع مشابه
Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells
The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombinati...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.45056